Combining medications like Trazodone and Wellbutrin can be a concern for some individuals due to potential interactions and side effects. In this guide, we’ll explore the safety, effectiveness, and considerations for taking Trazodone and Wellbutrin together.

Understanding Trazodone and Wellbutrin


Trazodone is an antidepressant medication primarily used to treat depression and manage insomnia. It belongs to a class of drugs known as serotonin antagonist and reuptake inhibitors (SARIs), which work by modulating serotonin levels in the brain to improve mood and promote sleep.

Wellbutrin (Bupropion)

Wellbutrin, also known by its generic name bupropion, is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder. It is also prescribed off-label for conditions like attention deficit hyperactivity disorder (ADHD) and smoking cessation. Wellbutrin works by inhibiting the reuptake of dopamine and norepinephrine, thereby improving mood and energy levels.

Can You Take Trazodone and Wellbutrin Together?

Potential Interaction

While Trazodone and Wellbutrin are often prescribed together, there is a potential for interaction. Both medications can increase serotonin levels in the brain, which may lead to a rare but serious condition called serotonin syndrome when taken in combination. Serotonin syndrome can cause symptoms such as confusion, hallucinations, rapid heart rate, and even seizures.

Monitoring and Adjustments

If your healthcare provider prescribes Trazodone and Wellbutrin together, they will likely monitor you closely for signs of serotonin syndrome, especially when starting or adjusting the dosage. They may also start with low doses and gradually increase them as needed while closely monitoring your response.

Considerations for Taking Trazodone and Wellbutrin Together

Timing of Administration

To minimize the risk of interactions, your healthcare provider may recommend taking Trazodone at night for its sleep-promoting effects and Wellbutrin in the morning to avoid potential sleep disturbances.

Individual Factors

The decision to combine Trazodone and Wellbutrin depends on various factors, including your medical history, current health status, and other medications you may be taking. It’s essential to provide your healthcare provider with a comprehensive list of all medications, supplements, and herbal products you use to avoid potential interactions.


While Trazodone and Wellbutrin can be taken together under the guidance of a healthcare provider, it’s essential to proceed with caution due to the potential for interactions. Always follow your provider’s instructions regarding dosage, timing, and monitoring to ensure safe and effective treatment. If you experience any concerning symptoms or side effects while taking these medications together, contact your healthcare provider immediately.

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