Introduction Glyburide

Glyburide, sold under the brand name Diabeta, is another sulfonylurea used in the treatment of type 2 diabetes. It functions similarly to glimepiride by stimulating insulin release from pancreatic beta cells.

Mechanism of Action Glyburide

Glyburide increases insulin secretion by binding to specific receptors on pancreatic beta cells. This leads to enhanced glucose uptake by tissues and decreased hepatic glucose production, helping to lower blood glucose levels.

Clinical Use Glyburide

Glyburide is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. It can be combined with other antidiabetic medications, including metformin and insulin, for improved efficacy.

Adverse Effects Glyburide

The most common side effects of Glyburide include hypoglycemia and weight gain. Hypoglycemia is a major concern and requires patients to be vigilant about monitoring their blood glucose levels, particularly when their physical activity or dietary intake changes.


Glyburide remains a valuable option in the armamentarium of type 2 diabetes treatments. Its ability to effectively lower blood glucose levels makes it an important tool, although it must be used with caution to prevent hypoglycemia.

One Response

Leave a Reply

Your email address will not be published. Required fields are marked *